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Courses

In the following course descriptions, L refers to courses with laboratory. In chemistry laboratories, safety goggles must be worn at all times. Students who require prescriptive lenses may wear prescription glasses under goggles; contact lenses may not be worn. Medical exceptions must be obtained from the laboratory director.

111-112-113. General Chemistry I, II, III (=EnvStd 111-112-113).
PQ: Good performance on the mathematics and physical sciences placement tests. This course sequence fulfills the Common Core requirement in the physical sciences. A discussion of atomic and molecular theories, chemical periodicity, and types of chemical reaction is followed in the first quarter by the chemical importance of pressure and temperature, phase diagrams, and acid-base and heterogeneous equilibria. During the second quarter the principles of chemical thermodynamics are covered, with applications to chemical and biological systems and to phase equilibria and electrochemistry. In the third quarter, ideas of atomic structure and chemical bonding are studied, along with the special features of liquids and solids and the chemistry of the representative elements. Lab work in Chem 111-112-113 includes some quantitative measurements, the properties of the important elements and their compounds, and experiments associated with the common ions and their separation and identification by semi-micro methods. Section A emphasizes the role of chemical and physical processes in the environment, especially in water and in the atmosphere. Section B has a more traditional organization. 111A P. Guyot-Sionnest, 111B R. S. Berry, Autumn; 112A J. Abbatt, 112B J. Light, Winter; 113A R. Clayton, 113B S. Sibener, Spring. L: Staff; Autumn, Winter, Spring.

121-122-123. Honors General Chemistry I, II, III.
PQ: Superior performance on the mathematics and physical sciences placement tests. This course sequence fulfills the Common Core requirement in the physical sciences. The subject matter and general program of Chem 121-122-123 is the same as that of Chem 111-112-113. However, this course is designed for the student deemed well prepared for a systematic study of chemistry. D. Levy, Autumn; S. Rice, Winter; G. Fleming, Spring. L: Staff; Autumn, Winter, Spring.

201-202. Inorganic Chemistry I, II.
PQ for Chem 201: Chem 111-112-113 or 121-122-123 and some knowledge of organic chemistry. PQ for Chem 202: Chem 201 and 222. The extraordinarily diverse chemistry of the elements is organized in terms of molecular structure, electronic properties, and chemical reactivity. Chem 201 concentrates on structure and bonding, solid state chemistry, and selected topics in the chemistry of the main group elements and coordination chemistry. Chem 202 focuses on organometallic chemistry, reactions, synthesis, and catalysis as well as bioinorganic chemistry. J. Burdett, Winter; B. Bosnich, Spring.

217-218-219 and 220-221-222. Organic Chemistry I, II, III.
PQ: An average grade of C or better in Chem 111-112-113 or 121-122-123, or consent of department. Two conceptually equivalent sequences of Organic Chemistry are offered. Both sequences start at the same point but use different examples to develop a conceptual understanding of organic structure and reactivity.

217-218-219. Organic Chemistry I, II, III (Variant A).
The fundamental structures of organic molecules and the spectroscopic methods used to define these structures are studied. An understanding of the reaction mechanisms of organic molecules is developed and extended to biological reactions and the molecules that catalyze these reactions. The structure and functional aspects of these molecules are used to develop the principles of chemical catalysis and an understanding of reaction mechanisms. Primary focus is placed on catalysis in biological reactions. W. Wulff, Autumn; J. Piccirilli, Winter; D. Lynn, Spring.

220-221-222. Organic Chemistry I, II, III (Variant B).
The fundamental structures of organic molecules and the spectroscopic methods used to define these structures are studied. An understanding of the reactions of organic molecules is developed and extended to the study of molecules with multiple functional groups. The chemistry of biologically important molecules such as carbohydrates, peptides, and nucleic acids is addressed and extended to the study of macromolecular structures of both natural and unnatural origin. L. Yu, Autumn; V. Rawal, Winter; P. Eaton, Spring.

223. Intermediate Organic Chemistry.
PQ: A grade of C or better in Chem 219 or 222, or consent of instructor. This course is intended to provide a more in-depth study of structure and reactivity in organic chemistry and bioorganic chemistry. It deals with aspects of multistep synthesis, elemental molecular orbital theory, pericyclic reactions, chemistry of macromolecules and biological macromolecules, and introduction to bioorganic chemistry. N. C. Yang. Autumn.

227. Advanced Organic/Inorganic Laboratory.
PQ: Chem 201 and 223, or consent of instructor. (Concurrent registration in 202 recommended.) A project approach is combined with an exposure to the more advanced techniques in organic and inorganic chemistry. Multistep syntheses, the synthesis of air-sensitive compounds, advanced chromatographic and spectroscopic characterization of products, and the handling of reactive intermediates are a part of the lab. G. Hillhouse. Spring.

261-262-263. Physical Chemistry I, II, III.
PQ: Chem 113 or 123, Math 201, and Phys 133. This three-quarter sequence contains a study of the application of physical and mathematical methods to the investigation of chemical systems.

261. Quantum Mechanics.
This course presents quantum mechanics, the Schrödinger wave equation with exact and approximate methods of solution, angular momentum, and atomic spectra and structure. K. Freed. Autumn.

262. Thermodynamics.
This course continues the sequence with the study of thermodynamic principles and applications. D. Levy. Winter.

263. Statistical Mechanics and Kinetics.
A discussion of statistical mechanics, kinetics, and surface chemistry. L. Butler. Spring.

267. Physical Chemistry Laboratory.
PQ: Chem 261 and concurrent enrollment in 262. An introduction to the principles and practice of physical chemical measurements. Techniques used in the design and construction of apparatus are discussed in lectures and practice is provided through lab exercises and experiments. Subjects include vacuum techniques, electronics, optics, use of computers in lab instrumentation, materials of construction, and data analysis. R. S. Berry. Winter.

268. Advanced Physical Chemistry Laboratory.
PQ: Chem 267. Students carry out research in physical chemistry in individual faculty laboratories. L. Butler. Spring.

299. Advanced Research in Chemistry.
PQ: Consent of a faculty sponsor and the undergraduate counselor. Open only to students eligible for honors who have submitted the College Reading and Research Course Form. May be taken either for a letter grade or for P/N or P/F. Advanced, individually guided research for College students concentrating in chemistry. Students may submit a written report covering their research activities for consideration for departmental honors. Staff. Summer, Autumn, Winter, Spring.

301. Advanced Inorganic Chemistry.
PQ: Chem 201 and 263, or consent of instructor. Group theory and its applications in inorganic chemistry are developed. These concepts are used in surveying the chemistry of inorganic compounds from the standpoint of quantum chemistry, chemical bonding principles, and the relationship between structure and reactivity. L. Sita. Autumn.

302. Chemical Applications of NMR Spectroscopy.
PQ: Chem 220, 221, 222 (or equivalents) and 227. This course is designed to provide the student with an in-depth working knowledge of modern fourier transform nuclear magnetic resonance (FT-NMR) spectroscopy and its chemical applications. Topics include fundamental theoretical and experimental considerations, determination of acquisition parameters, one-pulse NMR experiments, the nuclear overhauser effect (NOE), NMR of insensitive nuclei, heteronuclear NMR, evaluation and simulation of complex spin systems, acquisition of kinetic and thermodynamic parameters using dynamic NMR, two-dimensional NMR including the COSY, NOESY, and HETCOR experiments. L. Sita. Winter.

304. Organometallic Chemistry.
PQ: Chem 301, and 321 or 322. The preparation and properties of organometallic compounds, notably those of the transition elements; their reactions; and the concepts of homogeneous catalysis are discussed. G. Hillhouse. Spring.

306. Chemistry of the Elements.
PQ: Chem 201. The descriptive chemistries of the main-group elements and the transition metals are surveyed from a synthetic perspective, and reaction chemistry of inorganic molecules is systematically developed. B. Bosnich. Winter.

321. Physical Organic Chemistry.
PQ: Chem 222 and 262, or consent of instructor. This course focuses on the quantitative aspects of structure and reactivity: molecular orbital theory and the insight it provides into structures and properties of molecules, stereochemistry, thermochemistry, kinetics, substituent and isotope effects, and pericyclic reactions. M. Mrksich. Autumn.

322-323. Synthetic Organic Chemistry.
PQ: Chem 222 or consent of instructor. Chem 322 represents a close consideration of the mechanisms, applicability, and limitations of the major reactions in organic chemistry, and of stereochemical control in synthesis. Chem 323 represents a dissection of the most important syntheses of complex natural and unnatural products and covers such topics as synthesis planning and methodology, the logic of synthesis, and biogenesis. V. Rawal, Autumn; P. Eaton, Winter.

324. Physical Organic Chemistry II.
Topics include the mechanisms and fundamental theories of the free radicals and the related free radical reactions, biradical and carbene chemistry, and pericyclic and photochemical reactions. N. C. Yang, L. Yu. Winter.

325. Bioorganic Chemistry.
A goal of this course is to relate chemical phenomena with biological activities. The course covers two main areas: (1) chemical modifications of biological macromolecules and their potential effects and (2) the application of spectroscopic methods to elucidate the structure and dynamics of biologically relevant molecules. N. C. Yang, D. Lynn. Spring.

329. Polymer Chemistry.
PQ: Chem 222 and 263. This course introduces a broad range of polymerization reactions and discusses their mechanisms and kinetics. New concepts of polymerization and new materials of current interest are introduced and discussed. The physical properties of polymers, ranging from thermal properties to electrical and optical properties in both a solution state and a solid state are discussed, with the emphasis on structure/property relationship. Not offered 1996-97; will be offered 1997-98.

361. Wave Mechanics and Spectroscopy.
PQ: Chem 263. The introductory concepts, general principles, and applications of wave mechanics to spectroscopy are presented. J. Light. Autumn.

362. Quantum Mechanics.
PQ: Chem 361. A formal development of quantum mechanics is presented, including operators, matrix mechanics, and perturbation methods. The theory is applied to the description of the electronic structure of atoms and molecules. T. Oka. Winter.

363. Statistical Mechanics.
PQ: Chem 262. The general theory of statistical mechanics is applied to thermodynamics. Various perfect systems, some special distributions, and special topics are examined. K. Freed. Winter.

364. Chemical Thermodynamics.
PQ: Chem 262. The thermodynamics of equilibrium systems is discussed. S. Rice. Autumn.

365. Chemical Dynamics.
PQ: Chem 361 required, 363 recommended. This course develops a molecular-level description of chemical kinetics, reaction dynamics, and energy transfer in both gases and liquids. Topics include potential energy surfaces, collision dynamics and scattering theory, reaction rate theory, collisional and radiationless energy transfer, molecule-surface interactions, Brownian motion, time correlation functions, and computer simulations. S. Sibener, G. Fleming. Spring.

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